Experienced backs Josh Adams and Liam Williams are in but veteran back row Taulupe Faletau is not in the squad.
Evan Lloyd and Henry Thomas earn their first starts in the front row, while Dafydd Jenkins, the 2024 Six Nations captain, is at lock. Ben Thomas is selected ahead of Dan Edwards at fly-half, with the latter set to win his first cap from the bench.
Tom Rogers, Freddie Thomas and Blair Murray are set to make their Six Nations bows.
Wales line-up: 15-Williams; 14-Rogers, 13-Watkin, 12-Tompkins, 11-Adams; 10-B. Thomas, 9-T. Williams; 1-G. Thomas, 2-Lloyd, 3-H. Thomas, 4-Rowlands, 5-Jenkins, 6-Botham, 7-Morgan (capt), 8-Wainwright.
Replacements: 16-Dee, 17-Smith, 18-Assiratti, 19-F. Thomas, 20-Reffell, 21-R. Williams, 22-Edwards, 23-Murray.
